Different types of juvenile arthritis

Carol RoachStarred Page By Carol Roach, 2nd Dec 2015 | Follow this author | RSS Feed
Posted in Wikinut>Health>General Health>Children's Health

There are different types of juvenile arthritis. Researchers are rigorously trying to find cures.

Juvenile arthritis

As laypeople we tend to group diseases together as we do not have the medical background to do otherwise. People who have children with juvenile arthritis may need to know there is not just one kind of juvenile arthritis. According to ScienceDaily, “systemic juvenile idiopathic arthritis (SJIA) is a subtype of Juvenile idiopathic arthritis.”

Don’t let the big words fool you, idiopathic which you may come across in many diseases simply means the cause or causes of the origin of the disease are unknown. Systematic juvenile arthritis symptoms also includes:” systemic inflammation often resulting in fever, rash and serositis.

Kawasaki disease

“Serositis is the medical term for an inflammation of the lining of the lungs, heart, or abdomen and abdominal organs. The tissues that form the linings of these body parts are called serous tissues, and they form sacs around these important organs. An additional important function of the serous tissues is the secretion of lubricating fluid. Serositis symptoms are usually seen along with other symptoms in sufferers of various severe inflammatory illnesses, and can cause significant discomfort or pain.”

The study was published in BioMed Central's open access journal BMC Medicine showed that although the diseases are related Systematic juvenile arthritis and the more common form of juvenile arthritis, polyarticular juvenile idiopathic arthritis (POLY), do not follow the same inflammatory pathways. It appears that the immune system in association with systematic idiopathic arthritis may change over time.

Systematic idiopathic arthritis may look like a viral infection or Kawasaki disease. “Kawasaki disease is an illness that involves the skin, mouth, and lymph nodes, and most often affects kids under age 5. The cause is unknown, but if the symptoms are recognized early, kids with Kawasaki disease can fully recover within a few days. Untreated, it can lead to serious complications that can affect the heart.” If systematic idiopathic arthritis is not treated it can lead to chronic arthritis and the antibodies turn in on themselves rather than fight off the disease.

Treatment plans

Celera a team led by Prof Elizabeth Mellins who in collaboration with Stanford University School of Medicine to examine the genes in the blood of children with systematic idiopathic and polyarticular juvenile idiopathic arthritis.

“In our study we identified molecular pathways involved in both the systemic and arthritic components of SJIA. We discovered that the set of pathways involved in SJIA inflammation were different from those in POLY, perhaps explaining the differences in affected organs. This was especially true for the genes involved in increased ESR. For example, glucocorticoid signalling was more heavily involved in inflammation associated with SJIA than POLY, which may explain why non-glucocorticoid treatment is less effective for children with SJIA."

This information is important because it will help create better treatment plans for children with systematic idiopathic arthritis.



All photos taken from the public domain


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Tags

Kawasaki Disease, Systematic Idiopathic Arthritis

Meet the author

author avatar Carol Roach
Retired therapist and author of two books, freelance writer, newsletter editor, and blogger. I write, health, mental health, women's issues, animal , celebrity, history, and SEO articles.

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