Granulomatous: A Disease of the Lungs.

Hanson By Hanson, 6th Nov 2014 | Follow this author | RSS Feed
Posted in Wikinut>Health>General Health>Diseases & Infections

Granuloma annulare is a benign, asymptomatic, self-limited papular eruption found in patients of all ages.

Granulomatous Disease.

A granuloma is a small area of inflammation in tissue. Granulomas are most often the result of an infection and most frequently occur in the lungs, but can occur in other parts of the body as well. They typically cause no signs or symptoms and are found incidentally on a chest X-ray done for some other reason.

Granulomas are among the most commonly encountered abnormalities in pulmonary pathology and often pose a diagnostic challenge. Although most pathologists are aware of the need to exclude an infection in this setting, there is less familiarity with the specific histologic features that aid in the differential diagnosis.


Most granulomas in the lung are caused by mycobacterial or fungal infection. The diagnosis requires familiarity with the tissue reaction as well as with the morphologic features of the organisms, including appropriate interpretation of special stains.

The major non-infectious causes are:-

* Sarcoidosis.

* Wegener granulomatosis

* Hypersensitivity pneumonitis

* Hot tube lung

* Aspiration pneumonia

* Talc granulomatosis

Symptoms of Granulomatous

People with CGD can be generally healthy until they become infected with a disease.The severity of this infection can lead to prolonged hospitalizations for treatment. It may come as an inherited problem, or primary immunodeficiency disease (PIDD), which increases the body’s susceptibility to infections caused by certain bacteria and fungi. Granulomas are masses of immune cells that form at sites of infection or inflammation.

People with Chronic Granulomatous Disease (CGD) are unable to fight off common germs and get very sick from infections that would be mild in healthy people. This is because the presence of CGD makes it difficult for cells called neutrophils to produce hydrogen peroxide. The immune system requires hydrogen peroxide to fight specific kinds of bacteria and fungi.

These severe infections can include skin or bone infections and abscesses in internal organs (such as the lungs, liver or brain).

Children with CGD are often healthy at birth, but develop severe infections in infancy or early childhood. The most common form of CGD is genetically inherited in an X-linked manner, meaning it only affects boys. There are also autosomal recessive forms of CGD that affect both sexes.

Treatment of Granulomatous.

The best treatment plan for CGD is to prevent infections from occurring. Special preventative antibiotics are a mainstay of treatment for CGD. These greatly reduce the chances of infection.

People with CGD should also avoid swimming other than in chlorinated pools. Fresh or salt water may contain organisms that, while safe for healthy people, can cause infection in people with CGD.Treatment is directed toward stopping the inflammation process by suppressing the immune system.

Medications used to treat granulomatosis include high-dose cortisone(prednisone) and the immunosuppressive drug cyclophosphamide (Cytoxan). Recent reports also suggest that trimethoprim/sulfamethoxazole (Bactrim) can also be helpful to prevent relapse of disease activity in patients with granulomatosis.


Granulomatous Disease, Inflammation, Inflammation Of Multiple Organs, Inflammatory Disease, Pulmonary Disease, Pulmonary Diseases, Pulmonary Pathology

Meet the author

author avatar Hanson
Am a safety Professional down to earth, with passion for nature and the environment. My writing will focus on Safety and Environmental issues with other issues related to the children.

Share this page

moderator Steve Kinsman moderated this page.
If you have any complaints about this content, please let us know


Add a comment
Can't login?