Hashimoto Disease &Papillary Thyroid Cancer: A Paradoxical Relationship

davidbroom By davidbroom, 29th Aug 2016 | Follow this author | RSS Feed | Short URL http://nut.bz/3797uj0j/
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Interesting link between Hashimoto disease and papillary thyroid cancer. Patients who are diagnosed with Hashimoto disease, especially women, have an increased chance of developing papillary thyroid cancer. These patients should be closely monitored and followed-up by their doctors in order to be screened for papillary thyroid cancer.

Hashimoto Disease &Papillary Thyroid Cancer: A Paradoxical Relationship

Around the world, the chances of developing Hashimotos disease and papillary thyroid cancer (which is a specific type of thyroid cancer) are increasing. This issue has drawn a lot interest from researchers who are trying to find a link between Hashimoto’s disease and papillary thyroid cancer.

Understanding abnormalities of the thyroid gland

The most common cause of an under active thyroid gland – Hashimotos disease (also known as chroniclymphocytic thyroiditis, Hashimoto syndrome or Hashimoto thyroiditis) - is an autoimmune condition of the thyroid gland, wherethe body’s own immune system produces antibodies which attack the normal thyroid tissue. This autoimmune process results in damage and destruction of normal thyroid cells and therefore decreases the production of thyroid hormones. In order to compensate for the reduced production of thyroid hormones, the remaining thyroid cells enlarge which causes a swelling in the neckknown as a goiter.

The thyroid, like all other glands and organs in the body, is susceptible to developing cancer. The type of thyroid cancer that develops depends on what thyroid cell typeis affected. In this case, we shall discuss papillary thyroid cancer as the incidence of this condition is on the rise. Papillary thyroid cancer is caused by dysfunction of the papillary cells of the thyroid gland, the cause of which is thought to be due to the mutation of certain genes.

Thyroid cancers are mainly asymptomatic and most patients will present with a painless lump in the front of their necks that enlarges slowly. Differences in neck masses caused by thyroid conditions should be noted, as thyroid cancers cause small lumps on the thyroid gland and issues such as goiters cause an overall enlargement of the thyroid.

Does Hashimoto Disease Increase the Risk of Developing Papillary Thyroid Cancer?

It’s known that a link exists between Hashimoto disease and developing papillary thyroid cancer but the exact nature of this relationship is unknown. Patients with papillary thyroid cancer are twice as likely to have Hashimoto thyroiditis as the overall population. Also, women diagnosed with Hashimoto thyroiditis are more likely than men to develop papillary thyroid cancer.

It has also been suggested that Hashimoto syndrome may increase patients’ chances of developing papillary thyroid cancer. Unfortunately, the exact cause is not known but researchers do have a theory regarding this issue. Patients who have Hashimoto’s disease have an increased chance of developing mutations in the genes involved with papillary thyroid cell dysfunction.

How it is that Hashimoto syndrome can have protective features in patients withPapillary Thyroid Cancer

When patients develop papillary thyroid cancer, the presence of Hashimoto Disease actually increases patient survival and is associated with a decreased risk of death. The reason for this paradox is because patients who have Hashimoto disease are prone to less aggressive thyroid gene mutations. So, patients with Hashimoto’s disease can develop less aggressive papillary thyroid cancers than the general population, which means they have a better outcome.

Another explanation could be that since Hashimotos disease is an autoimmune condition, this can result in destruction of papillary cells of the thyroid that have the potential to become cancerous.

Conclusion
There’s an interesting link between Hashimoto disease and papillary thyroid cancer. Patients who are diagnosed with Hashimoto disease, especially women, have an increased chance of developing papillary thyroid cancer. These patients should be closely monitored and followed-up by their doctors in order to be screened for papillary thyroid cancer. Also, patients with Hashimoto thyroiditis who develop papillary thyroid cancer, have a better prognosis than those who develop papillary thyroid cancer without having Hashimoto disease.

Author Bio:
Sameer Ather is a cardiologist and data scientist based in Birmingham, Alabama. he has seen patients having difficulty navigating the complex world of health care. The problem was most acute in patients who had rare or serious conditions. For more information visit his site: https://www.xpertdox.com.

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Hashimotos Disease, Thyroid Cancer, Thyroid Disease, Thyroid Gland

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