Hiv prevention pill get protected

Martins O By Martins O, 13th Sep 2012 | Follow this author | RSS Feed
Posted in Wikinut>Health>Drugs & Medicines

WASHINGTON. History in the making.
The first ever daily pill to prevent the
contaction of HIV was approved on
monday by US regulators.

The HIV prevention Pill

WASHINGTON. History in the making.
The first ever daily pill to prevent the
contaction of HIV was approved on
monday by US regulators. This pill is to
be used in uninfected adults who are at
high risk of contacting the virus that
causes AIDS. This is a welcome
developement and a wonderful
breakthrough in research. Truvada, the
name given to the drug is made by
Gilead Sciences in California, and has
been on the market since 2004 was
approved by the Food and Drug
Administration for a new use as a
preventive tool to help ward off HIV in
otherwise healthy and uninfected
people, in combination with safe sex
and regular testing.  Truvada The pill
as pre-exposure prophylaxis (PrEP) has
been hailed by some AIDS experts as a
potent new tool against human
immunodeficiency virus. However,
some critics and health care providers
have expressed concern that it could
encourage risky sex behavior especially
among youths and adults. Adding, the
regimen is expensive and out of reach
of many at an estimated cost of around
$14,000 per year. “Truvada alone
should not be used to prevent HIV
infection,” Decleared Debra Birnkrant,
director of the division of antiviral
products at the FDA. “Truvada as PrEP
represents another effective, evidence-
based approach that can be added to
other prevention methods to help
reduce the spread of HIV in the world.”
The FDA said Truvada should be used
as “part of a comprehensive HIV
prevention strategy/ therapy that
includes other prevention methods,
such as safe sex practices, risk
reduction counseling, and regular HIV
testing.” Truvada was previously
approved as a treatment therapy for
people infected with HIV to be used in
combination with other antiretroviral
drugs namely Nevarphine, Stavudine
etc. The decision by the FDA followed
the advice of an independent panel in
May that supported Truvada for
prevention in uninfected people, after
clinical trials showed it could lower the
risk of HIV in gay men and heterosexual
couples. A study on Truvada, called the
iPrEx trial, published in 2010 in the New
England Journal of Medicine included
2,499 men who were sexually active
with other men but were not infected
with the virus that causes AIDS.
Participants were selected at random to
take a daily dose of Truvada — a
combination of 200 milligrams of
emtricitabine and 300 milligrams of
tenofovir disoproxil fumarate — or a
placebo. Those in the study who took
the drug regularly had almost 73
percent fewer infections. Across the
entire study, including those who had
not been as diligent in taking Truvada,
there were 44 percent fewer infections
than in those who took a placebo. other
studies has been documented Experts
described the result of these studies as
game-changing and the first
demonstration that an already-
approved oral drug could decrease the
chances of HIV infections. Although the
down side is the common side effects
which are same as those experienced
by people with HIV who were taking
Truvada, which includes diarrhea,
nausea, abdominal pain, headache,
nightmare and weight loss. However,
adherence rates — meaning how often
people in the study actually took the
drug daily — were low in the study of
men who have sex with men, just 30
percent, said Birnkrant. In the study of
heterosexual partners, adherence was
much higher, between 80 and 90
percent. Therefore, the drug label must
include specific instructions for health
care providers on how to counsel
potential users of the drug. The
producer of the drug must include a
warning that Truvada for PrEP “must
only be used by individuals who are
confirmed to be HIV-negative prior to
prescribing the drug and at least every
three months HIV testing should been
carried out during drug use.” Gilead
Sciences is also mandated to collect
samples from people who test positive
for HIV while taking the therapy and
analyze them for signs of drug
resistance and possible improvement.
As to critics that says the pill would
boost risky sex practices/ behavior and
make people abandon condoms as a
first line of protection, Birnkrant said
the studies have not shown that so far.
“We don’t really have any strong
evidence to show that condoms were
not used or that there was a decrease in
condom use when Truvada was used,”
she said. If you can’t tell if condoms
were used or not? How can u now
attribute the result to Truvada?
Hmmm.. Interestin isn’t it. The approval
of the drug is with the sole aim of
reducing the rate of new infections in
the United States, which have stayed
put in recent years at about 50,000
annually, she said thereby achieving a
key goal in decreasing new infections
by 25 percent by 2015.

Tags

Aids, Hiv, Hiv Aids, Hiv Virus, Immune System, Truvada

Meet the author

author avatar Martins O
Am a graduate of Psychology, I love writing, I believe that's the only to express one's true feeling without any second thought or influence. And finally read my posts and I promise to do same to yours

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