How Medicines Work In Your Body

Helen-FifeWriter By Helen-FifeWriter, 13th May 2013 | Follow this author | RSS Feed | Short URL http://nut.bz/ntow7m9k/
Posted in Wikinut>Health>Drugs & Medicines

When you take medication, a pill or cough mixture how does it work? Where inside the body does it go? Why can some medications be harmful? We swallow millions of chemist and doctor prescribed medications every year but how many of us actually understand just what we are putting inside our bodies?

We swallow millions of pills and potions every year!

What happens to medications once they are in our bodies? Where do they go? How do they get there? What functions do they carry out?

Millions of pills, syrups and potions are ingested in some form or another by humans on a daily basis. It may then be beneficial for us all to know exactly what happens inside our bodies when we have taken some form of medication.

The different ways medication can work

Medicines work in a variety of ways depending on what they are taken for and in what form. Some examples of why we take medication are:

pain relief
to fight infection
to fight disease
to supplement a deficiency
to assist a body mechanism to correct itself
to decrease an over abundance of a body substance
to balance systems and organs in the body
But in addition to what we take, there is also the route and form by which a medication is taken:

oral - tablet, capsule, syrup, drops etc.
sub-lingual, (under the tongue) - tablet, drops.
skin preparation - cream, ointments, gel, patches and so on.
injection - by hypodermic syringe.
IV - Intravenous - needle into a vein.
Into the bowel - suppository/enema.
inhalation - steam inhalation, crystals, inhaler.
drops - ear/eye/nose.
How medicines are processed by the body is an intricate process, but we can simplify this by breaking the steps down into four main areas:

Administration - we take in the medicine by the form and route as mentioned earlier.
Delivery - once the medicines are inside our body they move into the blood stream then into organs and tissues.
Performance - medicines will produce or induce effects.
Elimination - the body will wash out medicines and waste products associated with them.
So the type and route will have an affect on where the drug will enter the body and what areas the drug may target. For example, inhalations are primarily to assist with breathing.

The route and type of medication also has an effect on how quickly a drug will act. Intra-venous (IV) is a rapid method of medication administration, since the chemicals enter directly into the blood stream. Injections into a muscle, full of blood vessels is fast. Or Suppositories and enemas into the bowel can also be swift acting. This is due to the large surface area of the bowel that is packed with blood vessels, so absorbing the drugs very quickly. These last 3 routes also by-pass the stomach where some or all of the drug could be destroyed or diluted by the hydrochloric acid that's present.

The most common route for medications

The most common route is taking medication by mouth (oral). From here the medication has a journey to make that starts from our mouths to the target area.

Medicines in the digestive system

When medicines reach the stomach, some will start to dissolve. A few medicines will be absorbed into the stomach lining, others will move onto the small intestine. However, a number of tablets that are in capsule form or specially coated, will remain intact until they reach the small intestine. This is because if the medicine wasn't protected in this way, the contents would be destroyed by the hydrochloric acid in the stomach. In addition some other medications have special coverings to protect the stomach lining as these tablets may induce higher levels of hydrochloric acid that is harmful.

Medications not processed fully by the stomach move into the small intestine. They are absorbed into the lining of the small intestine. The small intestine or small bowel has three parts to it:

The duodenum
The Jejunum
The Ileum


From the small intestine medications will move into the blood stream. This happens because the medicines are moving from a high concentration fluid in the intestine to a lower concentration fluid - the blood.

Medicines in the the circulatory system

No matter what form a medicine takes they will be dissolved and enter the blood stream at some point. In this form the medicines are circulated around the body and so delivered to organs and tissues. This process is very fast. The heart can pump a full cycle of blood in about one minute. During this process the medicine molecules are being delivered throughout the body. The brain will receive the largest portion - about 16%. We will talk about the brain in more depth a little later. The effects of the medicine will continue to be active until *metabolism begins.

The metabolism for each medicine is different. In other words some are broken down and prepared for elimination more quickly than others. That is why some medicines will be given frequently, for example 2-4 hourly, others less so. In fact some medicines may already be breaking down when they passed through the liver for the first time - this is called 'first-pass effect' . Some form of tablets and capsules may have to go through the liver several times before they can be eliminated from the body.

(*Metabolism - the biochemical activity of a substance within a living organism.)

Medicines within the body tissues and cells

Within the body tissues we eventually get down to the cellular level. The cells of the body can absorb fluids and so will soak up the molecules of medicine from the blood fluid that surrounds them. Not all medicines will start to work at the same time. This is because different medicines all have their own specific molecules that will dissolve either quite quickly or more slowly than others. In addition some medicines find it easier to dissolve in human tissue than others.

Human cell membranes have a high content of fats. Therefore if you have a medicine that can dissolve in fat then they will begin to work more quickly than those that can't. This ability to dissolve in fat is a very important point on how fast a drug will begin to act in the body. Once the dissolved medications are within the cell this is where most of them do their work through biochemical reactions. They then re-enter the blood stream where they will once again enter the liver. Here they will be broken down further and prepared to be eliminated by the body.

Eliminating medicines from the body

The main organs associated with elimination of medicines is the liver and kidneys. Basically these organs sieve out toxic substances. The liver breaks them down through a series of complex metabolic reactions. These toxins/waste products are then stored by the liver until it is ready to send them to the kidneys. In the kidneys the prepared substances are further processed and then eliminated from the body through the urine.

Medications and the brain

How do medications interact with the brain?

As mentioned earlier medicines enter the blood stream once they have been dissolved and travel throughout the body to various organs. This obviously includes the brain. Once in the brain some medications can affect chemicals called neurotransmitters. These are special substances responsible for controlling the transmission of messages between brain cells - these type of cells are called neurones Specialised Neurotransmitters are also responsible for having an affect on people's feelings and moods.

However, it is not always possible for medicines to get access to the brain. This is because the brain has a safety device called the 'blood-brain barrier' - BBB for short.

This in effect helps to prevent things such as bacteria, toxins and unwanted molecules from entering the fluid that directly surrounds the brain. But what this does mean is, if infection infiltrates the defences then medications such as anti-biotics, whose molecules are large, cannot cross the BBB to fight the bacteria. Having said this, with infection comes inflammation and this is one condition that will weaken the barrier and may allow anti-biotics to filter through.

Other medications that are required to access the brain directly need to have specialised fat-soluble properties in order to get through the BBB's defences. In some areas of the brain the BBB is deliberately weak. This allows the brain to monitor the composition of the blood and to take action if adjustments are needed.

There are conditions and diseases that can weaken the BBB to a dangerous level allowing other harmful substances to pass through. Some of these conditions are:

Hypertension
Very high exposure to microwaves and radiation
Infections
Head trauma
Ischaemia - disease in the circulation causing lack or no blood supply to tissues
Inflammation
Pressure
Meningitis
Epilepsy
Multiple Sclerosis
Alzheimer's disease
HIV Encephalitis
Viruses

Factors that affect the medications you take

There are quite a number of factors that will influence both the absorption rate and the metabolism of medicines. They could also influence how effective the medication is.

Physical Factors

This includes your weight, age, fat mass, muscle mass. All these factors either speed up medicine absorption or slow it down.

If you have a good amount of fat mass for example, then it will have an affect on how long it takes to target the specific area and how effective the medicine will be when it gets there.

In relation to age - younger people tend to be able to metabolise and eliminate medications quicker and more thoroughly than older people. Therefore doctors will often moderate the dosage of tablets for an elderly person. Babies and young children have to have a moderated dosage as well since their bodies are still maturing. This means their organs could be more easily damaged by the toxic affects of medicines.

In addition, we are all genetically and chemically different. Some of us may tolerate a particular medicine more than others. This is why some people may suffer from either the *side effects or **adverse reaction of a medicine.

*Side effect - "An undesirable secondary effect of a drug" Encarta Dictionary
** Adverse reaction - "...undesirable or harmful results from a medication..." Encarta Dictionary.

If you experience any problems with medicines you should consult your doctor or pharmacist immediately.

Food

Food will slow down the absorption rate of medication. This can either be beneficial or detrimental to the medication's success rate. That is why it is always important to follow the instructions given either by a doctor or on the leaflet if bought at a chemist. As an example, instructions may include:

To be taken before food
To be taken either with or after food
To be taken after food
To be taken with a full glass of water


Other Medications/Chemicals

These can also have numerous affects on medications. For example, if some medications are taken at the same time, they could cancel out the benefits of each other. Some medications/chemicals will increase or decrease the rate of absorption and metabolism in the body. So again, that is why it is important to follow the instructions given to you or that are stated on instruction leaflets. For example you may see an instruction such as:

*Not to be taken with alcohol
*Do not operate machinery, or drive while taking this medication


I hope this article has been helpful to you in explaining how medications work in the body and the factors that can affect how they work. If you are ever unsure about any medications that you have - whether prescribed or bought - then speak to a doctor or pharmacist as soon as you can.

Photograph Attributions

1. IV/drip -
'Harmid' Public Domain via Wikimedia Commons


2. Human Diagram - 'ladyofhats' Public Domain via Wikimedia Commons

3.Pills & bottle -
'Ragesoss' CC-BY-SA 3.0 Unported via Wikimedia Commons

4. Blood Brain Barrier - Armin K├╝belbeck CC-BY 3.0 Unported via Wikimedia Commons.

Tags

Medication, Medicines, Pain Killers, Pain Medication, Pain Relief, Taking Medicines

Meet the author

author avatar Helen-FifeWriter
Hi to planet Earth. I love writing on many subjects that ranging from health through to my fascination of the paranormal and other mysteries.

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