Oxidative stress and Its Role in Neurological diseases

anguyen By anguyen, 12th Apr 2012 | Follow this author | RSS Feed | Short URL http://nut.bz/2224kv6q/
Posted in Wikinut>Health>General Health>Diseases & Infections

Mutations in our DNA occur everyday. Oxidative damage can increase the number of random mutations and be detrimental to our health. This article will explain how exposure oxidative products can lead to serious diseases such as Parkinson's disease and Alzheimer's disease.

Oxidative stress and Its Role in Neurological diseases

Spontaneous mutations are natural processes that occur in our everyday life. It enables living organisms to evolve and adapt to their current environment. Without mutations, we would be unable to have opposable thumbs, stand upright, or even walk on two legs. As beneficial as mutations can be, it can also be detrimental. Oxadative damage is an example of that.
Oxidative damage is a type of spontaneous lesion that generates mutations. The disruption of normal oxidation state of tissues in humans can be disturbed by the production of peroxides and free radicals in the environment, which can damage the cell's proteins and DNA through ATP (cell's energy) depletion and prevention of controlled cell death. This disruption in the human system can lead to major diseases, such as sickle cell disease, Parkinson's disease, and Alzheimer's disease.
The brain consumes 60% of the sugars in order to maintain our daily tasks. The brain also requires a continuous flow of oxygen, and deprivation of oxygen would cause permanent brain damage. Oxidative products, such as free radicals and peroxides, make our body require more oxygen, however our body cannot make enough enzymes to break down the peroxides and free radicals. As a result, the oxidative products use the fats of central nervous system, consisting of our brain and spinal cord, to react with. Research has shown that antioxidants can prevent the destruction oxidative products have on our bodies, but the blood-brain barrier, which acts like defensive wall against pathogens, prevents anything from entering the brain, rendering it ineffective. Brain cells under these conditions lead to a higher mutation rate, and thus, neurodegeneration.


Alzheimers Disease, Neurological Diseases, Oxidative Stress

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author avatar anguyen
A natural sciences student. I major in human biology. And I love to learn.

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